Electrochemical behaviors of diethylstilbestrol and its application in pharmacokinetics

被引：18

作者：

Bin, Q ^{[1
]}

Wei, W ^{[1
]}

Chi, YW ^{[1
]}

Chen, GN ^{[1
]}

机构：

[1] Fuzhou Univ, Dept Chem, Fujian 350002, Peoples R China

来源：

ANALYTICAL BIOCHEMISTRY | 2005年 / 336卷 / 02期

关键词：

diethylstilbestrol; electrochemistry; pharmacokinetics;

D O I：

10.1016/j.ab.2004.09.028

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The electrochemical behaviors of diethylstilbestrol (DES) at a glassy carbon electrode were investigated by cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry (DPV). Based on these, a sensitive and selective DPV method was developed for determination of DES. The linear response range of DES is 1.0 X 10(-4) -2.0 x 10(-6) mol/L and the detection limit was 8.0 X 10(-8) mol/L. The developed method has been used for the pharmacokinetics of DES in rabbit blood plasma. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：196 / 201

页数：6

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