Asymmetric catalytic Strecker reaction of N-phosphonyl imines with Et2AlCN using amino alcohols and BINOLs as catalysts

被引：68

作者：

Kaur, Parminder ^{[1
]}

Pindi, Suresh ^{[1
]}

Wever, Walter ^{[1
]}

Rajale, Trideep ^{[1
]}

Li, Guigen ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 24期

关键词：

MANNICH REACTIONS; DERIVATIVES; NITRILES; PROLINE; CYANIDE; AMIDES;

D O I：

10.1039/c0cc00287a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The asymmetric catalytic Strecker reaction of achiral N-phosphonyl imines with Et2AlCN has been established. Both free amino alcohols and BINOLs have been proven to be effective catalysts to afford excellent enantioselectivities and yields. The N-phosphonyl group can be readily cleaved under mild conditions and enable purification of crude products by simple washing with hexane. The cleaved N,N-dialkyl diamine auxiliary can be recovered quantitatively via n-BuOH extraction. The scope for both N-phosphonyl imines and catalysts was vastly studied for this new catalytic system.

引用

页码：4330 / 4332

页数：3

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