Influence of hydroxypropyl β-cyclodextrin on the corneal permeation of pilocarpine

被引：22

作者：

Aktas, Y

Ünlü, N ^{[1
]}

Orhan, M

Irkeç, M

Hincal, AA

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Dept Ophthalmol, TR-06100 Ankara, Turkey

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2003年 / 29卷 / 02期

关键词：

pilocarpine; ocular bioavailability; cyclodextrin; polyacrylic acid;

D O I：

10.1081/DDC-120016730

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The influence of hydroxypropyl beta-cyclodextrin (HPbetaCD) on the corneal permeation of pilocarpine nitrate was investigated by an in vitro permeability study using isolated rabbit cornea. Pupillary-response pattern to pilocarpine nitrate with and without HPbetaCD was examined in rabbit eye. Corneal permeation of pilocarpine nitrate was found to be four times higher after adding HPbetaCD into the formulation. The reduction of pupil diameter (miosis) by pilocarpine nitrate was significantly increased as a result of HPbetaCD addition into the simple aqueous solution of the active substance. The highest miotic response was obtained with the formulation prepared in a vehicle of Carbopol(R) 940. It is suggested that ocular bioavailability of pilocarpine nitrate could be improved by the addition of HPbetaCD.

引用

页码：223 / 230

页数：8

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