Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines

被引：37
作者：
Marques, Daiane S. [1 ]
Sandrini, Juliana Z. [1 ]
Boyle, Robert T. [1 ]
Marins, Luis F. [1 ]
Trindade, Gilma S. [1 ]
机构：
[1] Univ Fed Rio Grande, Inst Ciencias Biol, Programa Posgrad Ciencias Fisiol, BR-96201900 Rio Grande, RS, Brazil
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 06期
关键词：
CML; CD34; CD38; Oct-4; ABCB1; ABCG2; ABCC1; BINDING-CASSETTE TRANSPORTERS; EFFLUX PUMP; TRANSCRIPTIONAL REGULATION; TUMOR-CELLS; POU-DOMAIN; IN-VITRO; CANCER; EXPRESSION; DIFFERENTIATION; OCT-4;
D O I：
10.1016/j.leukres.2009.11.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The K562 cell line (chronic myeloid leukemia), sensitive to chemotherapy (non-MDR), and the Lucena cell line, resistant to chemotherapy (MDR) were investigated. The results suggest that both cell lines possess CD34+CD38- profiles of hematopoietic stem cell markers. The promoter regions of ABCB1, ABCG2 and ABCC1 genes contain binding sites for the Oct-4 transcripton factor, which is also considered a marker of tumor stem cells. Lucena cells showed an over-expression of the ABCB1 gene and a high expression of the Oct-4, ABCG2 and ABCC1 genes as compared to K562 cells. (C) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：757 / 762
页数：6
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