Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants

被引：0

作者：

Navarro, Pauline ^{[1
,2
,3
]}

Dalvai, Mathieu ^{[3
,4
]}

L. Charest, Phanie ^{[3
,4
]}

Herst, Pauline M. ^{[3
,4
]}

Lessard, Maryse ^{[3
,4
]}

Marcotte, Bruno ^{[2
,5
]}

Leblanc, Nadine ^{[1
,2
]}

Kimmins, Sarah ^{[6
,7
]}

Trasler, Jacquetta ^{[8
]}

MacFarlane, Amanda J. ^{[9
]}

Marette, Andre ^{[2
,5
]}

L. Bailey, Janice ^{[3
,4
]}

Jacques, Helene ^{[1
,2
]}

机构：

[1] Univ Laval, Fac Agr & Food Sci, Sch Nutr, 2425 Rue Agr, Quebec City, PQ G1V 0A6, Canada

[2] Univ Laval, Inst Nutr & Funct Foods, 2440 Blvd Hochelaga, Quebec City, PQ G1V 0A6, Canada

[3] Univ Laval, Ctr Rech Reprod Dev & Sante Intergenerat, 2425 Rue Agr, Quebec City, PQ G1V 0A6, Canada

[4] Univ Laval, Dept Anim Sci, Fac Agr & Food Sci, 2425 Rue Agr, Quebec City, PQ G1V 0A6, Canada

[5] Univ Laval, Quebec Heart & Lung Inst Cardiol Grp, Dept Med, Fac Med, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4G5, Canada

[6] McGill Univ, Dept Pharmacol & Therapeut, Fac Med, 3655 Promenade Sir William Osler,Room 1325, Montreal, PQ H3G 1Y6, Canada

[7] McGill Univ, Fac Agr & Environm Sci, Dept Anim Sci, 21111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada

[8] McGill Univ, Hlth Ctr Res Inst, Montreal Childrens Hosp, Dept Pediat, 1001 Blvd Decarie, Montreal, PQ H4A 3J1, Canada

[9] Hlth Canada, Nutr Res Div, 251 Promenade Sir Frederick Banting, Ottawa, ON K1A 0K9, Canada

来源：

ENVIRONMENTS | 2021年 / 8卷 / 03期

基金：

加拿大健康研究院;

关键词：

pollutants; folic acid; metabolic defects; insulin resistance; prenatal exposure; male lineage;

D O I：

10.3390/environments8030024

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Exposure to persistent organic pollutants (POPs) is associated with insulin resistance while folic acid (FA) may offer a protective effect. However, the paternal contribution to metabolic phenotypes in offspring is not well known yet. Hence, we investigated whether maternal exposure to POPs affects glucose homeostasis and whether maternal FA supplementation counteracts POP effects transmitted via male descendants. Sprague-Dawley founder dams (F0) were fed a diet containing 2 or 6 mg/kg of FA and were force-fed with either a POP mixture or corn oil for 9 weeks. Subsequent male descendants did not receive any treatment. Blood glucose, plasma insulin and C-peptide were measured during an oral glucose tolerance test in males aged 90 and 180 days from generation 1 (F1), 2 (F2) and 3 (F3). Prenatal POP exposure increased fasting glucose in 90-day-old F1 males and C-peptide in 90-day-old F2 males. Prenatal FA supplementation decreased C-peptide in 90 and 180-day-old F1 males. In 180-day-old F3 males, FA supplementation counteracted POPs on fasting and postglucose C-peptide, indicating reduced insulin secretion. Prenatal exposure to an environmentally relevant POP mixture caused abnormalities in glucose homeostasis that are transmitted from one generation to the next through the paternal lineage. Prenatal FA supplementation counteracted some of the deleterious effects of POPs on glucose homeostasis.

引用

页数：17

共 57 条

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