The Role of Sialyl-Tn in Cancer

被引：159

作者：

Munkley, Jennifer ^{[1
]}

机构：

[1] Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 03期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

sialyl-Tn; O-glycans; ST6GalNAc1; cancer; glycosylation; COSMC; ACTIVE SPECIFIC IMMUNOTHERAPY; PROTEIN O-GLYCOSYLATION; TUMOR-ASSOCIATED GLYCOPROTEIN-72; MONOCLONAL-ANTIBODY B72.3; MOLECULAR CHAPERONE COSMC; METASTATIC BREAST-CANCER; HUMAN-COLON-CANCER; SIALOSYL-TN; CARBOHYDRATE ANTIGENS; GASTRIC-CANCER;

D O I：

10.3390/ijms17030275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid alpha-2,6 linked to GalNAc alpha-O-Ser/Thr and is associated with an adverse outcome and poor prognosis in cancer patients. The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development. This review discusses how the role of sTn in cancer development and tumour cell invasiveness might be organ specific and occur through different mechanisms depending on each cancer type or subtype. As the sTn-antigen is expressed early in carcinogenesis targeting sTn in cancer may enable the targeting of tumours from the earliest stage.

引用

页数：9

共 94 条

[81]

SCHMITT FC, 1995, VIRCHOWS ARCH, V427, P251

[82] Regulation of the metastatic cell phenotype by sialylated glycans [J].

Schultz, Matthew J. ;

Swindall, Amanda F. ;

Bellis, Susan L. .

CANCER AND METASTASIS REVIEWS, 2012, 31 (3-4) :501-518

[83] The ST6GalNAc-I sialyltransferase localizes throughout the golgi and is responsible for the synthesis of the tumor-associated Sialyl-Tn O-glycan in human breast cancer [J].

Sewell, R ;

Bäckström, M ;

Dalziel, M ;

Gschmeissner, S ;

Karlsson, H ;

Noll, T ;

Gätgens, J ;

Clausen, H ;

Hansson, GC ;

Burchell, J ;

Taylor-Papadimitriou, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (06) :3586-3594

[84] REACTIVITY OF THE MONOCLONAL-ANTIBODY B72.3 WITH FETAL ANTIGEN - CORRELATION WITH EXPRESSION OF TAG-72 IN HUMAN CARCINOMAS [J].

STANICK, D ;

SCHUSS, A ;

MISHRIKI, Y ;

CHAO, S ;

THOR, A ;

LUNDY, J .

CANCER INVESTIGATION, 1988, 6 (03) :279-287

[85]

Ta A, 1997, INFLAMM BOWEL DIS, V3, P254

[86]

TAKAHASHI I, 1993, CANCER, V72, P1836, DOI 10.1002/1097-0142(19930915)72:6<1836::AID-CNCR2820720607>3.0.CO

[87]

2-7

[88] Galectin-3 and metastasis [J].

Takenaka, Y ;

Fukumori, T ;

Raz, A .

GLYCOCONJUGATE JOURNAL, 2002, 19 (7-9) :543-549

[89] Mucin-type O-glycosylation and its potential use in drug and vaccine development [J].

Tarp, Mads Agervig ;

Clausen, Henrik .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2008, 1780 (03) :546-563

[90]

THOR A, 1986, CANCER RES, V46, P3118

← 1 2 3 4 5 6 7 8 9 10 →