Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic Example: Methyleugenol, CASRN: 93-15-2

被引：32
作者：
Smith, Benjamin
Cadby, Peter
Leblanc, Jean-Charles
Setzer, R. Woodrow
机构：
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2010年 / 48卷
关键词：
Methyleugenol; Margin of exposure; MoE; NATURALLY-OCCURRING ALKENYLBENZENES; POST-LABELING ANALYSIS; DNA-ADDUCTS; ESTRAGOLE BIOACTIVATION; PROTEIN ADDUCTS; TRANS-ANETHOLE; IN-VIVO; SAFROLE; RAT; MOUSE;
D O I：
10.1016/j.fct.2009.10.036
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The weight of evidence points to weak genotoxic activity of methyleugenol, the Putative genotoxic carcinogen being 1'-sulphate ester metabolite. Dose response modelling of the data for methyleugenol gave a BMDL10 for male rat liver adenoma or carcinoma (combined) of 7.9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation. (C) 2009 ILSI Europe. Published by Elsevier Ltd. All rights reserved.
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页码：S89 / S97
页数：9
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