Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems

被引：25

作者：

Benninger, Richard K. P.

Hofmann, Oliver

Onfelt, Bjorn

Munro, Ian

Dunsby, Chris

Davis, Daniel M.

Neil, Mark A. A.

French, Paul M. W.

de Mello, Andrew J.

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Phys, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 13期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

fluorescence; imaging; intercalation; microfluidics; microreactors;

D O I：

10.1002/anie.200604112

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Light across the channel: The utility of time-resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA-dye binding interactions. The combination of time-resolved fluorescence imaging and continuous-flow microfluidics provides a powerful route to the resolution and quantification of multistate biological systems with precise spatial and temporal reaction control. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2228 / 2231

页数：4

共 32 条

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