Methylphenidate and atomoxetine increase histamine release in rat prefrontal cortex

被引：47

作者：

Horner, Weldon E. ^{[1
]}

Johnson, David E. ^{[1
]}

Schmidt, Anne W. ^{[1
]}

Rollema, Hans ^{[1
]}

机构：

[1] Pfizer Inc, Global Res & Dev, Dept Neurosci, Groton, CT 06340 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 558卷 / 1-3期

关键词：

histamine; methylphenidate; atomoxetine; ADHD; microdialysis;

D O I：

10.1016/j.ejphar.2006.11.048

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using microdialysis in rat prefrontal cortex, we found that 1 mg/kg of the stimulant methylphenidate and the non-stimulant atomoxetine, two widely used treatments for Attention Deficit/Hyperactivity Disorder (ADHD), produce robust increases in the extracellular levels of histamine, which plays a key role in attention, learning and memory. While the clinical response to ADHD drugs is typically attributed to modulation of norepinephrine and dopamine, this finding suggests enhanced histamine release may contribute to their efficacy as ADHD treatments. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：96 / 97

页数：2

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