Tissue engineering by decellularization and 3D bioprinting

被引：183

作者：

Garreta, Elena ^{[1
]}

Oria, Roger ^{[2
,3
]}

Tarantino, Carolina ^{[1
]}

Pla-Roca, Mateu ^{[4
]}

Prado, Patricia ^{[1
]}

Fernandez-Aviles, Francisco ^{[5
]}

Maria Campistol, Josep ^{[6
]}

Samitier, Josep ^{[7
,8
,9
]}

Montserrat, Nuria ^{[1
,9
]}

机构：

[1] Inst Bioengn Catalonia IBEC, Pluripotent Stem Cells & Activat Endogenous Tissu, C Baldiri Reixac 15-21, Barcelona 08028, Spain

[2] Inst Bioengn Catalonia IBEC, C Baldiri Reixac 15-21, Barcelona 08028, Spain

[3] Univ Barcelona, Barcelona, Spain

[4] Inst Bioengn Catalonia IBEC, Nanotechnol Platform, C Baldiri Reixac 15-21, Barcelona 08028, Spain

[5] Univ Complutense Madrid, Dept Cardiol, Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon,Fac Med, C Dr Esquerdo 46, Madrid 28007, Spain

[6] Univ Barcelona, Hosp Clin, IDIBAPS, E-08036 Barcelona, Spain

[7] Inst Bioengn Catalonia IBEC, Nanobioengn Grp, C Baldiri Reixac 15-21, Barcelona 08028, Spain

[8] Univ Barcelona, Dept Engn Elect, E-08028 Barcelona, Spain

[9] Networking Biomed Res Ctr Bioengn Biomat & Nanome, Madrid, Spain

来源：

MATERIALS TODAY | 2017年 / 20卷 / 04期

关键词：

PLURIPOTENT STEM-CELLS; PERFUSION DECELLULARIZATION; ORTHOTOPIC TRANSPLANTATION; MECHANICAL-PROPERTIES; BIOLOGIC SCAFFOLDS; BIOREACTOR SYSTEM; SKELETAL-MUSCLE; ACELLULAR HUMAN; PORCINE LUNGS; MATRIX;

D O I：

10.1016/j.mattod.2016.12.005

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Discarded human donor organs have been shown to provide decellularized extracellular matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell sources to satisfy the need of multiple cells types in order to fully repopulate human organ-derived dECM scaffolds has opened new venues for the use of human pluripotent stem cells (hPSCs) for recellularization. In addition, three-dimensional (3D) bioprinting techniques are advancing towards the fabrication of biomimetic cellladen biomaterial constructs. Here, we review recent progress in decellularization/recellularization and 3D bioprinting technologies, aiming to fabricate autologous tissue grafts and organs with an impact in regenerative medicine.

引用

页码：166 / 178

页数：13