An efficient synthesis of (2S)-2-[4-((1R, 2S)-2-hydroxycyclopentylmethyl)phenyl]propionic acid

被引：0

作者：

Mandai, T

Yamakawa, T

机构：

[1] Kurashiki Univ Sci & Arts, Dept Chem Technol, Kurashiki, Okayama 7128505, Japan

[2] Inst Nippon Chemiphar Co Ltd, Misato, Saitama 3410005, Japan

来源：

SYNLETT | 2000年 / 06期

关键词：

anti-inflammatory agent; 2-arylpropionic acid derivative; lipase; asymmetric acetylation; kinetic resolution;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of (2S)-2-[4-((1R,1S)-2-hydroxy-cyclopentylmethyl)phenyl]propionic acid via lipase-catalyzed kinetic resolution of (-)-N-[(1S)-1-phenylethyl]-(+/-)-2-[4-(trans-2-hydroxycyclopentylmethyl)phenyl] propionamide is successfully accomplished.

引用

页码：862 / 864

页数：3

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