An efficient synthesis of (2S)-2-[4-((1R, 2S)-2-hydroxycyclopentylmethyl)phenyl]propionic acid

被引：0
|
作者：
Mandai, T
Yamakawa, T
机构：
[1] Kurashiki Univ Sci & Arts, Dept Chem Technol, Kurashiki, Okayama 7128505, Japan
[2] Inst Nippon Chemiphar Co Ltd, Misato, Saitama 3410005, Japan
来源：
SYNLETT | 2000年 / 06期
关键词：
anti-inflammatory agent; 2-arylpropionic acid derivative; lipase; asymmetric acetylation; kinetic resolution;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of (2S)-2-[4-((1R,1S)-2-hydroxy-cyclopentylmethyl)phenyl]propionic acid via lipase-catalyzed kinetic resolution of (-)-N-[(1S)-1-phenylethyl]-(+/-)-2-[4-(trans-2-hydroxycyclopentylmethyl)phenyl] propionamide is successfully accomplished.
引用
收藏
页码：862 / 864
页数：3
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