Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia

被引:26
|
作者
Sica, AL
Greenberg, HE
Scharf, SM
Ruggiero, DA
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Med, Div Pulm & Crit Care, New Hyde Park, NY 11040 USA
[2] Yeshiva Univ Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Med, Div Pulm & Crit Care, New Hyde Park, NY 11040 USA
[3] Columbia Univ Coll Phys & Surg, Dept Psychiat & Anat, New York, NY 10032 USA
[4] Columbia Univ Coll Phys & Surg, Dept Cell Biol, New York, NY 10032 USA
[5] Neurol Res Inst Lubec, Lubec, ME USA
基金
美国国家卫生研究院;
关键词
chronic-intermittent hypoxia; rat; c-fos; insular cortex; medial prefrontal cortex;
D O I
10.1016/S0006-8993(00)02170-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate. retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical circuits that adaptively regulate sympathetic and cardiovascular activities. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:204 / 210
页数:7
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