Relevance of and New Developments in Serology for Toxoplasmosis

被引:84
作者
Dard, Celine [1 ,2 ]
Fricker-Hidalgo, Helene [1 ]
Brenier-Pinchart, Marie-Pierre [1 ,2 ]
Pelloux, Herve [1 ,2 ]
机构
[1] Ctr Hosp & Univ Grenoble Alpes, Lab Parasitol Mycol, Grenoble, France
[2] Univ Grenoble Alpes, Inst Albert Bonniot, INSERM, U1209,CNRS,UMR 5309, Grenoble, France
关键词
TOXOPLASMA-GONDII INFECTION; IMMUNOSORBENT AGGLUTINATION ASSAY; B-CELL EPITOPES; GOLDMANN-WITMER COEFFICIENT; REAL-TIME PCR; CONGENITAL TOXOPLASMOSIS; OCULAR TOXOPLASMOSIS; PREGNANT-WOMEN; IMMUNOGLOBULIN-M; SOUTH-AMERICA;
D O I
10.1016/j.pt.2016.04.001
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Toxoplasmosis is a widespread parasitic disease caused by the intracellular parasite Toxoplasma gondii with a wide spectrum of clinical outcomes. The biological diagnosis of toxoplasmosis is often difficult and of paramount importance because clinical features are not sufficient to discriminate between toxoplasmosis and other illnesses. Serological tests are the most widely used biological tools for the diagnosis of toxoplasmosis worldwide. This review focuses on the crucial role of serology in providing answers to the most important questions related to the epidemiology and diagnosis of toxoplasmosis in human pathology. Notwithstanding their undeniable importance, serological tools need to be continuously improved and the interpretation of the ensuing results remains complex in many circumstances.
引用
收藏
页码:492 / 506
页数:15
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