A versatile method for evaluating the controlled-release performance of microcapsules

被引：3

作者：

Cui, Kai-di ^{[1
,3
]}

Li, Bei-xing ^{[1
,2
]}

Huang, Xue-ping ^{[1
,2
]}

He, Lei-ming ^{[1
,2
]}

Zhang, Da-xia ^{[1
,2
]}

Mu, Wei ^{[2
,3
]}

Liu, Feng ^{[1
,3
]}

机构：

[1] Shandong Agr Univ, Coll Plant Protect, Shandong Prov Key Lab Biol Vegetable Dis & Insect, Tai An 271018, Shandong, Peoples R China

[2] Shandong Agr Univ, Res Ctr Pesticide Environm Toxicol, Tai An 271018, Shandong, Peoples R China

[3] Shandong Agr Univ, Key Lab Pesticide Toxicol & Applicat Tech, Tai An 271018, Shandong, Peoples R China

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2017年 / 529卷

基金：

中国国家自然科学基金;

关键词：

Microcapsule; Dissolution test; Release; Syringe filters; Wall material; DRUG-RELEASE; MECHANICAL-PROPERTIES; DIALYSIS; SYSTEM; MICROENCAPSULATION; POLYMERIZATION; ENCAPSULATION; MICROSPHERES; FABRICATION; PESTICIDES;

D O I：

10.1016/j.colsurfa.2017.05.060

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Sustained-release profile is an important component in the quality control of microcapsules. In the current study, we propose a reliable, convenient, and versatile strategy to assess the controlled-release performance of MCs under artificial, simulated conditions. Dissolution tests were performed using an experimental device equipped with syringe filters. The optimum experimental conditions utilized 80% v/v methanol (3 ml) as a release medium at each sampling point, Nylon 6 filters (13 mm diameter, 0.22 mu m pore size) as diffusion barriers, and a sampling regime based on predetermined changed intervals. Validation tests demonstrated that this strategy possessed favorable universality for three wall materials (polyurea, polyurethane and urea-formaldehyde) and three core materials (phoxim, pyraclostrobin and clomazone), as all sampling points had standard errors below 3.4%. Our proposed method also showed apparent advantages in experimental precision and the demand for a release medium compared with dynamic dialysis.

引用

页码：80 / 87

页数：8