DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents

被引:14
作者
citoglu, Senem [1 ]
Coskun, Ozlem Duyar [2 ]
Tung, Le Duc [3 ,4 ]
Onur, Mehmet Ali [5 ]
Kim Thanh, Nguyen Thi [3 ,4 ]
机构
[1] Hacettepe Univ, Inst Sci, Dept Nanotechnol & Nanomed, TR-06800 Ankara, Turkey
[2] Hacettepe Univ, Dept Phys Engn, Thin Film Preparat & Characterizat Lab, TR-06800 Ankara, Turkey
[3] Royal Inst Great Britain, UCL Healthcare Biomagnet & Nanomat Labs, 21 Albemarle St, London W1S 4BS, England
[4] UCL, Dept Phys & Astron, Biophys Grp, Gower St, London WC1E 6BT, England
[5] Hacettepe Univ, Dept Biol, Fac Sci, TR-06800 Ankara, Turkey
基金
英国工程与自然科学研究理事会;
关键词
cytotoxicity; HeLa; iron oxide cubic nanoparticles; meso-2; 3-dimercaptosuccinic acid (DMSA); SAR; SURFACE MODIFICATION; OLEIC-ACID; MAGNETIC HYPERTHERMIA; IN-VIVO; BIOCOMPATIBILITY; NANOCRYSTALS; EFFICIENCY; SHAPE; SIZE;
D O I
10.2217/nnm-2020-0467
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Aim: Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. Methods: Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. Results: DMSA functionalized cubic IONPs with an edge length of 24.5 +/- 1.9 nm had a specific absorption rate value of 197.4 W/g(Fe) (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 x 10(10), 6.6 x 10(10) and 9.9 x 10(10) NP/mL for 24, 48 and 72 h. Conclusion: To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.
引用
收藏
页码:925 / 941
页数:18
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