Method for Small-Scale Production of Deuterochloroform

被引：4

作者：

Tansukawat, Natha D. ^{[1
]}

See, Alyaa E. ^{[1
]}

Jiranuntarat, Sadudee ^{[1
]}

Corbin, Joshua R. ^{[1
]}

Schomaker, Jennifer M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, 1101 Univ Ave, Madison, WI 53706 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 15期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CHLOROFORM-D;

D O I：

10.1021/acs.joc.8b01018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deuterochloroform (CDCl3) is a common deuterated solvent for nuclear magnetic resonance (NMR) analyses. The synthesis of significant amounts of CDCl3 for both research use and large undergraduate organic laboratories in a safe and inexpensive manner is appealing. Herein, we describe a convenient laboratory scale preparation of CDCl3 that employs a reduction and decarboxylation of hexachloro-2-propanone (HCP) catalyzed by various pyridines. A PVP catalyst gives cleaner reaction and greater catalyst stability through multiple rounds of recycling, justifying its higher cost compared to pyridine.

引用

页码：8739 / 8742

页数：4

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