Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

被引：973

作者：

Banales, Jesus M. ^{[1
]}

Cardinale, Vincenzo ^{[2
]}

Carpino, Guido ^{[3
]}

Marzioni, Marco ^{[4
]}

Andersen, JesperB. ^{[5
]}

Invernizzi, Pietro ^{[6
,7
]}

Lind, Guro E. ^{[8
]}

Folseraas, Trine ^{[9
]}

Forbes, Stuart J. ^{[10
]}

Fouassier, Laura ^{[11
,12
]}

Geier, Andreas ^{[13
]}

Calvisi, Diego F. ^{[14
]}

Mertens, Joachim C. ^{[15
]}

Trauner, Michael ^{[16
]}

Benedetti, Antonio ^{[4
]}

Maroni, Luca ^{[4
]}

Vaquero, Javier ^{[11
,12
]}

Macias, Rocio I. R. ^{[17
]}

Raggi, Chiara ^{[6
]}

Perugorria, Maria J. ^{[1
]}

Gaudio, Eugenio ^{[18
]}

Boberg, Kirsten M. ^{[9
]}

Marin, Jose J. G. ^{[17
]}

Alvaro, Domenico ^{[2
]}

机构：

[1] Donostia Univ Hosp, Ikerbasque, Dept Liver & Gastrointestinal Dis, Biodonostia Hlth Res Inst,CIBERehd, Paseo Dr Begiristain S-N, E-20014 San Sebastian, Spain

[2] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Viale Univ 37, I-00185 Rome, Italy

[3] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, Piazza Lauro De Bosis 6, I-00135 Rome, Italy

[4] Polytech Univ Marche, Dept Clin & Mol Sci, Via Tronto 10, I-60020 Ancona, Italy

[5] Univ Copenhagen, Biotech Res & Innovat Ctr, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark

[6] Humanitas Clin & Res Ctr, Via Manzoni 56, I-20089 Milan, Italy

[7] Univ Milano Bicocca, Program Autoimmune Liver Dis, Int Ctr Digest Hlth, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy

[8] Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Mol Oncol, Oslo, Norway

[9] Oslo Univ Hosp, Rikshosp, Div Canc Med Surg & Transplantat, Dept Transplantat Med, Pb 4950 Nydalen, N-0424 Oslo, Norway

[10] Univ Edinburgh, MRC Ctr Regenerat Med, 49 Little France Crescent, Edinburgh EH16 4SB, Midlothian, Scotland

[11] INSERM, UMR S938, Ctr Rech St Antoine, 184 Rue Faubourg, F-75571 Paris 12, France

[12] Fdn ARC, 9 Rue Guy Moquet, F-94803 Villejuif, France

[13] Univ Hosp Wurzburg, Dept Internal Med 2, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany

[14] Univ Med Greifswald, Inst Pathol, Friedrich Loffler Str 23e, D-17489 Greifswald, Germany

[15] Univ Zurich Hosp, Div Gastroenterol & Hepatol, Ramistr 100, CH-8091 Zurich, Switzerland

[16] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[17] Univ Salamanca, Dept Physiol & Pharmacol, Expt Hepatol & Drug Targeting HEVEFARM, IBSAL,CIBERehd, Campus Miguel de Unamuno,EID S-09, Salamanca 37007, Spain

[18] Univ Roma La Sapienza, Dept Anat Histol Forens Med & Orthoped Sci, Via Alfonso Borelli 50, I-00161 Rome, Italy

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2016年 / 13卷 / 05期

基金：

英国医学研究理事会;

关键词：

GROWTH-FACTOR-RECEPTOR; FINE-NEEDLE-ASPIRATION; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN INTRAHEPATIC CHOLANGIOCARCINOMA; BILIARY-TRACT CARCINOMA; INDUCE CYCLOOXYGENASE-2 EXPRESSION; PRIMARY SCLEROSING CHOLANGITIS; CANCER-ASSOCIATED FIBROBLASTS; NUCLEOSIDE TRANSPORTER 1; HEPATIC STELLATE CELLS;

D O I：

10.1038/nrgastro.2016.51

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of biliary tract differentiation. CCA is the second most common primary liver tumour and the incidence is increasing worldwide. CCA has high mortality owing to its aggressiveness, late diagnosis and refractory nature. In May 2015, the "European Network for the Study of Cholangiocarcinoma" (ENS-CCA: www.enscca.org or www.cholangiocarcinoma.eu) was created to promote and boost international research collaboration on the study of CCA at basic, translational and clinical level. In this Consensus Statement, we aim to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer. Moreover, future directions on basic and clinical investigations and plans for the ENS-CCA are highlighted.

引用

页码：261 / 280

页数：20

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