The biological and toxicological activity of gases and vapors

被引：35

作者：

Abraham, Michael H. ^{[1
]}

Sanchez-Moreno, Ricardo ^{[1
]}

Gil-Lostes, Javier ^{[1
]}

Acree, William E., Jr. ^{[2
]}

Cometto-Muniz, J. Enrique ^{[3
]}

Cain, William S. ^{[3
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

[2] Univ N Texas, Dept Chem, Denton, TX 76203 USA

[3] Univ Calif San Diego, Dept Surg Otolaryngol, Chemosensory Percept Lab, La Jolla, CA 92093 USA

来源：

TOXICOLOGY IN VITRO | 2010年 / 24卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Volatile compound; Quantitative structure-activity relationship; Linear free energy relationship; Nasal pungency threshold; Eye irritation thresholds; Odor detection threshold; Upper respiratory tract irritation in mice; QUANTITATIVE STRUCTURE-ACTIVITY; VOLATILE ORGANIC-COMPOUNDS; EYE IRRITATION; INHALATION ANESTHETICS; PHYSICOCHEMICAL PROPERTIES; PREDICTION; THRESHOLDS; TOXICITY; QSAR; AIR;

D O I：

10.1016/j.tiv.2009.11.009

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A large amount of data on the biological and toxicological activity of gases and vapors has been collected from the literature. Processes include sensory irritation thresholds, the Alarie mouse test, inhalation anesthesia, etc. It is shown that a single equation using only five descriptors (properties of the gases and vapors) plus a set of indicator variables for the given processes can correlate 643 biological and non-lethal toxicological activities of 'non-reactive' compounds with a standard deviation of 0.36 log unit. The equation is scaled to sensory irritation thresholds obtained by the procedure of Cometto-Muniz, and Cain provides a general equation for the prediction of sensory irritation thresholds in man. It is suggested that differences in biological/toxicological activity arise primarily from transport from the gas phase to a receptor phase or area, except for odor detection thresholds where interaction with a receptor(s) is important. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：357 / 362

页数：6

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