The synthetic n-terminal peptide of human lactoferin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii

被引：71
作者：
Dijkshoorn, L
Brouwer, CPJM
Bogaards, SJP
Nemec, A
van den Broek, PJ
Nibbering, PH
机构：
[1] Leiden Univ, Ctr Med, Dept Infect Dis, NL-2300 RC Leiden, Netherlands
[2] AM Pharma, Bunnik, Netherlands
[3] Natl Publ Hlth Inst, Prague, Czech Republic
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 12期
关键词：
D O I：
10.1128/AAC.48.12.4919-4921.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). Therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant A. baumannii.
引用
收藏
页码：4919 / 4921
页数：3
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