The synthetic n-terminal peptide of human lactoferin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii

被引：72
作者：
Dijkshoorn, L
Brouwer, CPJM
Bogaards, SJP
Nemec, A
van den Broek, PJ
Nibbering, PH
机构：
[1] Leiden Univ, Ctr Med, Dept Infect Dis, NL-2300 RC Leiden, Netherlands
[2] AM Pharma, Bunnik, Netherlands
[3] Natl Publ Hlth Inst, Prague, Czech Republic
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 12期
关键词：
D O I：
10.1128/AAC.48.12.4919-4921.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). Therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant A. baumannii.
引用
收藏
页码：4919 / 4921
页数：3
相关论文
共 16 条
[1]   Comparison of outbreak and nonoutbreak Acinetobacter baumannii strains by genotypic and phenotypic methods [J].
Dijkshoorn, L ;
Aucken, H ;
GernerSmidt, P ;
Janssen, P ;
Kaufmann, ME ;
Garaizar, J ;
Ursing, J ;
Pitt, TL .
JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (06) :1519-1525
[2]   Evaluation of amplified ribosomal DNA restriction analysis for identification of Acinetobacter genomic species [J].
Dijkshoorn, L ;
van Harsselaar, B ;
Tjernberg, I ;
Bouvet, PJM ;
Vaneechoutte, M .
SYSTEMATIC AND APPLIED MICROBIOLOGY, 1998, 21 (01) :33-39
[3]   Enhanced Th1 response to Staphylococcus aureas infection in human lactoferrin-transgenic mice [J].
Guillén, C ;
McInnes, IB ;
Vaughan, DM ;
Kommajosyula, S ;
Van Berkel, PHC ;
Leung, BP ;
Aguila, A ;
Brock, JH .
JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :3950-3957
[4]   Cationic peptides: a new source of antibiotics [J].
Hancock, REW ;
Lehrer, R .
TRENDS IN BIOTECHNOLOGY, 1998, 16 (02) :82-88
[5]   Lactoferrin stimulates a Staphylococcus aureus killing activity of bovine phagocytes in the mammary gland [J].
Kai, K ;
Komine, K ;
Komine, Y ;
Kuroishi, T ;
Kozutsumi, T ;
Kobayashi, J ;
Ohta, M ;
Kitamura, H ;
Kumagai, K .
MICROBIOLOGY AND IMMUNOLOGY, 2002, 46 (03) :187-194
[6]   Citywide clonal outbreak of multiresistant Acinetobacter baumannii and Pseudomonas aeruginosa in Brooklyn, NY -: The preantibiotic era has returned [J].
Landman, D ;
Quale, JM ;
Mayorga, D ;
Adedeji, A ;
Vangala, K ;
Ravishankar, J ;
Flores, C ;
Brooks, S .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (13) :1515-1520
[7]  
Livermore David M, 2002, Curr Opin Investig Drugs, V3, P218
[8]   The threat from the pink corner [J].
Livermore, DM .
ANNALS OF MEDICINE, 2003, 35 (04) :226-234
[9]   Long-term predominance of two pan-European clones among multi-resistant Acinetobacter baumannii strains in the Czech Republic [J].
Nemec, A ;
Dijkshoorn, L ;
van der Reijden, TJK .
JOURNAL OF MEDICAL MICROBIOLOGY, 2004, 53 (02) :147-153
[10]   Acinetobacter ursingii sp nov and Acinetobacter schindleri sp nov., isolated from human clinical specimens [J].
Nemec, A ;
De Baere, T ;
Tjernberg, I ;
Vaneechoutte, M ;
van der Reijden, TJK ;
Dijkshoorn, L .
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2001, 51 :1891-1899
12