Filaggrin's fuller figure: A glimpse into the genetic architecture of atopic dermatitis

被引：84
作者：
Sandilands, Aileen
Smith, Frances J. D.
Irvine, Alan D.
McLean, W. H. Irwin
机构：
[1] Univ Dundee, Epithelial Genet Grp, Human Genet Unit, Dundee DD1 9SY, Scotland
[2] Our Ladys Hosp Sick Children, Dept Paediat Dermatol, Dublin 12, Ireland
[3] Univ Dublin Trinity Coll, Dept Clin Med, Dublin 2, Ireland
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 06期
关键词：
D O I：
10.1038/sj.jid.5700876
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.
引用
收藏
页码：1282 / 1284
页数：3
相关论文
共 11 条
[11]   Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris [J].
Smith, FJD ;
Irvine, AD ;
Terron-Kwiatkowski, A ;
Sandilands, A ;
Campbell, LE ;
Zhao, YW ;
Liao, HH ;
Evans, AT ;
Goudie, DR ;
Lewis-Jones, S ;
Arseculeratne, G ;
Munro, CS ;
Sergeant, A ;
O'Regan, G ;
Bale, SJ ;
Compton, JG ;
DiGiovanna, JJ ;
Presland, RB ;
Fleckman, P ;
McLean, WHI .
NATURE GENETICS, 2006, 38 (03) :337-342
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