Filaggrin's fuller figure: A glimpse into the genetic architecture of atopic dermatitis

被引：84

作者：

Sandilands, Aileen

Smith, Frances J. D.

Irvine, Alan D.

McLean, W. H. Irwin

机构：

[1] Univ Dundee, Epithelial Genet Grp, Human Genet Unit, Dundee DD1 9SY, Scotland

[2] Our Ladys Hosp Sick Children, Dept Paediat Dermatol, Dublin 12, Ireland

[3] Univ Dublin Trinity Coll, Dept Clin Med, Dublin 2, Ireland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 06期

关键词：

D O I：

10.1038/sj.jid.5700876

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Prevalent mutations in the FLG gene underlie the common skin disorder ichthyosis vulgaris and are significant risk factors for atopic dermatitis (eczema). The recent publication of a strategy to sequence this difficult gene identifies a spectrum of both prevalent and rare mutations that collectively have a significant impact on susceptibility to atopic disease.

引用

页码：1282 / 1284

页数：3

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