New insights into the function of Atg9

被引：92

作者：

Webber, Jemma L. ^{[1
]}

Tooze, Sharon A. ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, London WC2A 3PX, England

来源：

FEBS LETTERS | 2010年 / 584卷 / 07期

关键词：

p38 MAPK interacting protein; p38 mitogen activated protein kinase; Autophagosome; PRE-AUTOPHAGOSOMAL STRUCTURE; PROTEIN TARGETING PATHWAY; SACCHAROMYCES-CEREVISIAE; VESICLE FORMATION; NONSPECIFIC AUTOPHAGY; ACTIN CYTOSKELETON; SIGNALING PATHWAYS; CVT PATHWAY; MAP KINASE; CELL-DEATH;

D O I：

10.1016/j.febslet.2010.01.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is a lysosomal degradation pathway that is essential for cellular homeostasis. Identification of more than 30 autophagy related proteins including a multi-spanning membrane protein, Atg9, has increased our understanding of the molecular mechanisms involved in autophagy. Atg9 is required for autophagy in several eukaryotic organisms although its function is unknown. Recently, we identified a novel interacting partner of mAtg9, p38 MAPK interacting protein, p38IP. We summarise recent data on the role of Atg9 trafficking in yeast and mammalian autophagy and discuss the role of p38IP and p38 MAPK in regulation of mAtg9 trafficking and autophagy. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1319 / 1326

页数：8

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