Tumor necrosis factor alpha expression is increased in maternal microvascular endothelial cells in preeclampsia

被引：3

作者：

Lee, Dennis K. ^{[1
]}

Nevo, Ori ^{[1
]}

机构：

[1] Univ Toronto, Dept Obstet & Gynecol, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

来源：

HYPERTENSION IN PREGNANCY | 2021年 / 40卷 / 03期

关键词：

Tumor necrosis factor alpha; endothelin; apelin; hypertension; TNF-ALPHA; PLACENTAL HYPOXIA; ACTIVATION; APELIN; HYPERTENSION; PATHOGENESIS; VASOPRESSIN; ARTERIES; RECEPTOR; MODELS;

D O I：

10.1080/10641955.2021.1921794

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: The aim of this study was to explore the expression and effects of tumor necrosis factor alpha (TNF alpha) in maternal endothelial cells in preeclampsia (PE). Methods: Expression levels in primary microvascular endothelial cells (MVEC) isolated from patients with severe preeclampsia (PE) and normal pregnancies were determined by RT-qPCR with or without treatment of TNF alpha and inhibitors for downstream signaling. Results: PE MVEC exhibited increased basal TNF alpha expression. TNF alpha treatment increased TNF alpha, VCAM, and endocan expression in MVEC. Conclusion: TNF alpha expression is increased in PE MVEC and the treatment of these cells with exogenous TNF alpha modifies their gene expression.

引用

页码：193 / 201

页数：9

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