Breaking the COPI monopoly on Golgi recycling

被引：63

作者：

Storrie, B ^{[1
]}

Pepperkok, R

Nilsson, T

机构：

[1] Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA

[2] European Mol Biol Lab, Biol & Biophys Programme, D-69117 Heidelberg, Germany

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 09期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(00)01818-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The unexpected discovery of a transport pathway from the Golgi to the endoplasmic reticulum (ER) independent of COPI coat proteins sheds light on how Golgi resident enzymes and protein toxins gain access to the ER from as far as the trans Golgi network. This new Pathway provides an explanation for how membrane is recycled to allow for an apparent concentration of anterograde cargo at distinct stages of the secretory pathway. As signal-mediated COPI-dependent recycling also involves the concentration of resident proteins into retrograde COPI vesicles, the main bulk of lipids must be recycled possibly through a COPI-independent pathway.

引用

页码：385 / 391

页数：7

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