Interleukin-1β and TNF-α act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones

被引：136
作者：
Mårtensson, K [1 ]
Chrysis, D [1 ]
Sävendahl, L [1 ]
机构：
[1] Karolinska Inst, Dept Woman & Child Hlth, Pediat Endocrinol Unit, Stockholm, Sweden
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期
关键词：
interleukin-1; TNF; growth plate; chondrocytes; insulin-like growth factor I;
D O I：
10.1359/JBMR.040805
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We hypothesized that pro-inflammatory cytokines can act locally in the growth plate to impair longitudinal growth. In a model of cultured fetal rat metatarsal bones, we found that IL-1beta and TNF-alpha act in synergy to inhibit longitudinal growth, an effect linked to decreased proliferation and increased apoptosis of growth plate chondrocytes. IGF-I could partially reverse all these effects.
引用
收藏
页码：1805 / 1812
页数：8
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