Interleukin-1β and TNF-α act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones

被引：136

作者：

Mårtensson, K ^{[1
]}

Chrysis, D ^{[1
]}

Sävendahl, L ^{[1
]}

机构：

[1] Karolinska Inst, Dept Woman & Child Hlth, Pediat Endocrinol Unit, Stockholm, Sweden

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期

关键词：

interleukin-1; TNF; growth plate; chondrocytes; insulin-like growth factor I;

D O I：

10.1359/JBMR.040805

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We hypothesized that pro-inflammatory cytokines can act locally in the growth plate to impair longitudinal growth. In a model of cultured fetal rat metatarsal bones, we found that IL-1beta and TNF-alpha act in synergy to inhibit longitudinal growth, an effect linked to decreased proliferation and increased apoptosis of growth plate chondrocytes. IGF-I could partially reverse all these effects.

引用

页码：1805 / 1812

页数：8

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