Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

被引：10
|
作者：
Madsen, A. M. Rosendahl [1 ]
Holm, A. [1 ]
Jensen, T. G. [1 ]
Knudsen, E. [1 ]
Lundgaard, H. [1 ]
Skov, M. N. [1 ]
Uldum, S. A. [2 ]
Kemp, M. [1 ]
机构：
[1] Odense Univ Hosp, Dept Clin Microbiol, Odense, Denmark
[2] Statens Serum Inst, Copenhagen, Denmark
来源：
JOURNAL OF HOSPITAL INFECTION | 2017年 / 96卷 / 04期
关键词：
Legionella; Nosocomial infection; Whole-genome sequencing; LEGIONELLA-PNEUMOPHILA; SCHEME;
D O I：
10.1016/j.jhin.2017.04.020
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：292 / 295
页数：4
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