Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease

被引：10
|
作者：
Madsen, A. M. Rosendahl [1 ]
Holm, A. [1 ]
Jensen, T. G. [1 ]
Knudsen, E. [1 ]
Lundgaard, H. [1 ]
Skov, M. N. [1 ]
Uldum, S. A. [2 ]
Kemp, M. [1 ]
机构：
[1] Odense Univ Hosp, Dept Clin Microbiol, Odense, Denmark
[2] Statens Serum Inst, Copenhagen, Denmark
来源：
JOURNAL OF HOSPITAL INFECTION | 2017年 / 96卷 / 04期
关键词：
Legionella; Nosocomial infection; Whole-genome sequencing; LEGIONELLA-PNEUMOPHILA; SCHEME;
D O I：
10.1016/j.jhin.2017.04.020
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Acquisition of Legionnaires' disease is a serious complication of hospitalization. Rapid determination of whether or not the infection is caused by strains of Legionella pneumophila in the hospital environment is crucial to avoid further cases. This study investigated the use of whole-genome sequencing to identify the source of infection in hospital-acquired Legionnaires' disease. Phylogenetic analyses showed close relatedness between one patient isolate and a strain found in hospital water, confirming suspicion of nosocomial infection. It was found that whole-genome sequencing can be a useful tool in the investigation of hospital-acquired Legionnaires' disease. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：292 / 295
页数：4
相关论文
共 50 条
  • [1] Diving Deep Into Hospital-Acquired Legionella pneumophila With Whole-Genome Sequencing
    Beatson, Scott A.
    Bartley, Paul B.
    CLINICAL INFECTIOUS DISEASES, 2017, 64 (09) : 1260 - 1262
  • [2] Hospital-acquired Legionnaires' disease: new developments
    Stout, JE
    Yu, VL
    CURRENT OPINION IN INFECTIOUS DISEASES, 2003, 16 (04) : 337 - 341
  • [3] Genomic Diversity of Hospital-Acquired Infections Revealed through Prospective Whole-Genome Sequencing-Based Surveillance
    Mustapha, Mustapha M.
    Srinivasa, Vatsala R.
    Griffith, Marissa P.
    Cho, Shu-Ting
    Evans, Daniel R.
    Waggle, Kady
    Ezeonwuka, Chinelo
    Snyder, Daniel J.
    Marsh, Jane W.
    Harrison, Lee H.
    Cooper, Vaughn S.
    Van Tyne, Daria
    MSYSTEMS, 2022, 7 (03)
  • [4] Whole-Genome Sequence Analysis of Streptococcus pneumoniae Strains That Cause Hospital-Acquired Pneumonia Infections
    Chang, Bin
    Morita, Masatomo
    Lee, Ken-ichi
    Ohnishi, Makoto
    JOURNAL OF CLINICAL MICROBIOLOGY, 2018, 56 (05)
  • [5] Tracking Cefoperazone/Sulbactam Resistance Development In vivo in A. baumannii Isolated from a Patient with Hospital-Acquired Pneumonia by Whole-Genome Sequencing
    Liu, Xiaofen
    Zheng, Huajun
    Zhang, Weipeng
    Shen, Zhen
    Zhao, Miao
    Chen, Yuancheng
    Sun, Li
    Shi, Jun
    Zhang, Jing
    FRONTIERS IN MICROBIOLOGY, 2016, 7
  • [6] Evaluation of Whole-Genome Sequencing for Identification and Typing of Vibrio cholerae
    Greig, David R.
    Schaefer, Ulf
    Octavia, Sophie
    Hunter, Ebony
    Chattaway, Marie A.
    Dallman, Timothy J.
    Jenkins, Claire
    JOURNAL OF CLINICAL MICROBIOLOGY, 2018, 56 (11)
  • [7] The use of genome sequencing to investigate an outbreak of hospital-acquired mucormycosis in transplant patients
    Marek, Caitlyn
    Croxen, Matthew A.
    Dingle, Tanis C.
    Bharat, Amrita
    Schwartz, Ilan S.
    Wiens, Rhoda
    Smith, Stephanie
    TRANSPLANT INFECTIOUS DISEASE, 2019, 21 (05)
  • [8] Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia
    Tohru Fujiwara
    Noriko Fukuhara
    Ryo Funayama
    Naoki Nariai
    Mayumi Kamata
    Takeshi Nagashima
    Kaname Kojima
    Yasushi Onishi
    Yoji Sasahara
    Kenichi Ishizawa
    Masao Nagasaki
    Keiko Nakayama
    Hideo Harigae
    Annals of Hematology, 2014, 93 : 1515 - 1522
  • [9] Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia
    Fujiwara, Tohru
    Fukuhara, Noriko
    Funayama, Ryo
    Nariai, Naoki
    Kamata, Mayumi
    Nagashima, Takeshi
    Kojima, Kaname
    Onishi, Yasushi
    Sasahara, Yoji
    Ishizawa, Kenichi
    Nagasaki, Masao
    Nakayama, Keiko
    Harigae, Hideo
    ANNALS OF HEMATOLOGY, 2014, 93 (09) : 1515 - 1522
  • [10] Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease
    Prokopenko, Dmitry
    Sakornsakolpat, Phuwanat
    Fier, Heide Loehlein
    Qiao, Dandi
    Parker, Margaret M.
    McDonald, Merry-Lynn N.
    Manichaikul, Ani
    Rich, Stephen S.
    Barr, R. Graham
    Williams, Christopher J.
    Brantly, Mark L.
    Lange, Christoph
    Beaty, Tern H.
    Crapo, James D.
    Silverman, Edwin K.
    Cho, Michael H.
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2018, 59 (05) : 614 - 622
12345