Restriction of T-cell receptor repertoires in idiopathic CD4+ lymphocytopenia

被引：19
作者：
Signorini, S
Pirovano, S
Fiorentini, S
Stellini, R
Bianchi, V
Albertini, A
Imberti, L
机构：
[1] Spedali Civili, Lab Biotecnol, Terzo Lab Anal, I-25123 Brescia, Italy
[2] Univ Brescia, Inst Chem, I-25121 Brescia, Italy
[3] Univ Brescia, Inst Microbiol, I-25121 Brescia, Italy
[4] Spedali Civili, Prima Div Malattie Infett, I-25125 Brescia, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 110卷 / 02期
关键词：
CD4(+) lymphocytopenia; alpha/beta T cells; gamma/delta T cells; immunodeficiency; T-cell receptor repertoire;
D O I：
10.1046/j.1365-2141.2000.02166.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report that alpha/beta and gamma/delta T-cell repertoires of three patients with idiopathic CD4(+) lymphocytopenia, who showed different clinical manifestations and outcomes over time, were highly restricted. The disruption of T-cell repertoires does not influence the susceptibility to infections: the first patient was unable to attain a protective response to mycobacterium, the second showed clinical improvement and the third did not develop opportunistic infections, These results indicate that idiopathic CD4(+) lymphocytopenia could give rise to mono-/oligoclonal T-cell expansions, but the degree of repertoire disturbance is not indicative of the severity of disease progression.
引用
收藏
页码：434 / 437
页数：4
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