The effect of ethanolamine on acute carbon tetrachloride intoxication

被引：0
|
作者：
Murakami, T
Nagamura, Y
Hirano, K
机构：
[1] Gifu Pharmaceut Univ, Dept Pharmaceut, Gifu 502, Japan
[2] Fujita Hlth Univ, Sch Hlth Sci, Dept Clin Chem, Aichi 47011, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1998年 / 21卷 / 01期
关键词：
ethanolamine; liver injury; carbon tetrachloride; hepatocellular regeneration; 5-bromo-2 '-deoxyuridine; ATP;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of ethanolamine on injured liver were investigated by oral administration of ethanolamine to male ddY mice 24 h after carbon tetrachloride (CCl4) injection. The serum aminotransferase activities in mice with liver injury were reduced by ethanolamine treatment (10-30 mg/kg body weight). Drastically increased regenerative reaction of ethanolamine treated-CCl4 injured liver was also observed through an increase in 5-bromo-2'-deoxyuridine uptake. ATP concentration in liver tissue was recovered by administration of ethanolamine. These results suggest that oral administration of ethanolamine accelerates recovery from CCl4-induced liver injury.
引用
收藏
页码：84 / 86
页数：3
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