Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

被引：75
作者：
Zhou, Chao [1 ,2 ]
Tsai, Tsung-Han [1 ,2 ]
Adler, Desmond C. [1 ,2 ,3 ]
Lee, Hsiang-Chieh [1 ,2 ]
Cohen, David W. [4 ]
Mondelblatt, Amy [4 ]
Wang, Yihong [4 ]
Connolly, James L. [4 ]
Fujimoto, James G. [1 ,2 ]
机构：
[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[3] LightLab Imaging Inc, Westford, MA 01886 USA
[4] Harvard Univ, Dept Pathol, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA
来源：
OPTICS LETTERS | 2010年 / 35卷 / 05期
基金：
加拿大自然科学与工程研究理事会;
关键词：
GROWTH-FACTOR RECEPTOR; CONTRAST AGENTS; NANOPARTICLES; THERAPY; CANCER; CELLS;
D O I：
10.1364/OL.35.000700
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 mu m deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells. (C) 2010 Optical Society of America
引用
收藏
页码：700 / 702
页数：3
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