Optimization of prednisolone acetate-loaded chitosan microspheres using a 23 factorial design for preventing restenosis

被引：12

作者：

Sarisozen, Can ^{[1
]}

Arica, Betuel ^{[1
]}

Orman, Mehmet N. ^{[2
]}

Hincal, A. Atilla ^{[1
]}

Calis, Sema ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey

[2] Ege Univ, Fac Med, Dept Biostat & Med Informat, TR-35100 Bornova, Turkey

来源：

DRUG DELIVERY | 2010年 / 17卷 / 03期

关键词：

Microspheres; prednisolone acetate; chitosan; factorial design; spray-drying; DRUG-ELUTING STENTS; CONTROLLED-RELEASE; DELIVERY; ENCAPSULATION;

D O I：

10.3109/10717541003667780

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2<SU3</SU) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 +/- 6.7%) and encapsulation efficiency (45.7 +/- 0.3%), and released the drug at a constant rate in 11 days.</.

引用

页码：178 / 186

页数：9

共 29 条

[21] Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(ε-caprolactone) stent cuff [J].