Striatal Activity during Intentional Switching Depends on Pattern Stability

被引:35
作者
De Luca, Cinzia [1 ,2 ]
Jantzen, Kelly J. [3 ,4 ]
Comani, Silvia [1 ,2 ,5 ]
Bertollo, Maurizio [2 ,6 ]
Kelso, J. A. Scott [4 ,7 ]
机构
[1] Gabriele dAnnunzio Univ, Dept Clin Sci & Bioimaging, I-66013 Chieti, Italy
[2] Gabriele dAnnunzio Univ, Behav Imaging & Neural Dynam Ctr, I-66013 Chieti, Italy
[3] Western Washington Univ, Bellingham, WA 98225 USA
[4] Florida Atlantic Univ, Ctr Complex Syst & Brain Sci, Boca Raton, FL 33431 USA
[5] Citta S Angelo, Casa Cura Privata Villa Serena, I-65013 Pescara, Italy
[6] Gabriele dAnnunzio Univ, Dept Basic & Appl Med Sci, I-66013 Chieti, Italy
[7] Univ Ulster, Intelligent Syst Res Ctr, Lderry BT48 7JL, North Ireland
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
BASAL-GANGLIA; ACTION SELECTION; HUMAN BRAIN; COORDINATION DYNAMICS; BIMANUAL COORDINATION; COMPUTATIONAL MODEL; RESPONSE SELECTION; PHASE-TRANSITIONS; INHIBITION; CIRCUITS;
D O I
10.1523/JNEUROSCI.2673-09.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The theoretical framework of coordination dynamics posits complementary neural mechanisms to maintain complex behavioral patterns under circumstances that may render them unstable and to voluntarily switch between behaviors if changing internal or external conditions so demand. A candidate neural structure known to play a role in both the selection and maintenance of intentional behavior is the basal ganglia. Here, we use functional magnetic resonance imaging to explore the role of basal ganglia in intentional switching between bimanual coordination patterns that are known to differ in their stability as a function of movement rate. Key measures of pattern dynamics and switching were used to map behavior onto the associated neural circuitry to determine the relation between specific behavioral variables and activated brain areas. Results show that putamen activity is highly sensitive to pattern stability: greater activity was observed in bilateral putamen when subjects were required to switch from a more to a less stable pattern than vice versa. Since putamen activity correlated with pattern stability both before and during the switching process, its role may be to select desired actions and inhibit competing ones through parametric modulation of the intrinsic dynamics. Though compatible with recent computational models of basal ganglia function, our results further suggest that pattern stability determines how the basal ganglia efficiently and successfully select among response alternatives.
引用
收藏
页码:3167 / 3174
页数:8
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