SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer 2015

被引：28

作者：

Aranda, E. ^{[1
,2
]}

Aparicio, J. ^{[3
]}

Alonso, V. ^{[2
,4
]}

Garcia-Albeniz, X. ^{[5
,6
]}

Garcia-Alfonso, P.

Salazar, R. ^{[7
]}

Valladares, M. ^{[8
]}

Vera, R. ^{[9
]}

Vieitez, J. M. ^{[2
,10
]}

Garcia-Carbonero, R. ^{[2
,11
]}

机构：

[1] Univ Cordoba, Hosp Reina Sofia, Inst Maimonides Invest Biomed IMIBIC, Serv Oncol Med, Cordoba, Spain

[2] Minist Econ & Competit, RTICC, ISCiii, Madrid, Spain

[3] Hosp Univ & Politecn La Fe, Valencia, Spain

[4] Hosp Univ Miguel Servet, Zaragoza, Spain

[5] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA USA

[6] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[7] Inst Catala Oncol LHospitalet, Barcelona, Spain

[8] Complexo Hosp Univ, La Coruna, Spain

[9] Complejo Hosp Navarra, Pamplona, Spain

[10] Hosp Univ Cent Asturias, Oviedo, Spain

[11] Hosp Univ 12 Octubre, Madrid, Spain

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2015年 / 17卷 / 12期

关键词：

Colorectal cancer; Metastases; Chemotherapy; Targeted agents; Surgery; Guidelines; RANDOMIZED PHASE-III; 1ST-LINE TREATMENT; OPEN-LABEL; RAS MUTATIONS; COMBINATION CHEMOTHERAPY; IRINOTECAN FOLFIRI; PLUS CAPECITABINE; PANITUMUMAB PLUS; BEVACIZUMAB; FLUOROURACIL;

D O I：

10.1007/s12094-015-1434-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is the second leading cause of cancer dead in Spain. About half the patients will eventually develop distant metastases. However, as treatment options are expanding, prognosis has steadily improved over the last decades. Management of advanced CRC should be discussed within an experienced multidisciplinary team to select the most appropriate systemic treatment (chemotherapy and targeted agents) and to integrate surgical or ablative procedures when indicated. Disease site and extent, resectability, tumor biology and gene mutations, clinical presentation, patient preferences, and comorbidities are key factors to design a customized treatment plan. The aim of these guidelines is to provide synthetic recommendations for managing advanced CRC patients.

引用

页码：972 / 981

页数：10

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