Functional imaging of working memory and peripheral endothelial function in middle-aged adults

被引：24
作者：
Gonzales, Mitzi M. [1 ]
Tarumi, Takashi [2 ]
Tanaka, Hirofumi [2 ]
Sugawara, Jun [2 ]
Swann-Sternberg, Tali [1 ]
Goudarzi, Katayoon [1 ]
Haley, Andreana P. [1 ,3 ]
机构：
[1] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA
[3] Univ Texas Imaging Res Ctr, Austin, TX USA
来源：
BRAIN AND COGNITION | 2010年 / 73卷 / 02期
关键词：
Working memory; Magnetic resonance imaging; Cardiovascular disease; Endothelium; Middle-aged; Cognition; WHITE-MATTER HYPERINTENSITIES; NITRIC-OXIDE SYNTHASE; CEREBRAL-BLOOD-FLOW; CARDIOVASCULAR-DISEASE; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; OLDER-ADULTS; COGNITIVE FUNCTION; BRAIN ACTIVATION; RISK-FACTORS;
D O I：
10.1016/j.bandc.2010.04.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (beta = 0.338, p = 0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36) = 2.66, p = 0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：146 / 151
页数：6
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