TiO2 Nanoparticle Catalyzed Rapid Synthesis of Spiroxindole-Pyrrolidine in Aqueous Medium and Evaluation of their Antimicrobial Properties

被引：23

作者：

Ramesh, Pambala ^{[1
]}

Reddy, Marri Sameer ^{[2
]}

Kumar, Nandigama Satish ^{[3
]}

Rathod, Balaji ^{[4
]}

Prakasham, R. S. ^{[4
]}

Chowan, L. Raju ^{[1
]}

机构：

[1] Cent Univ Gujarat, Ctr Appl Chem, Sect 30, Gandhinagar 382030, Guj, India

[2] Cent Univ Gujarat, Sch Chem Sci, Sect 30, Gandhinagar 382030, Guj, India

[3] GITAM, Dept Chem, Visakhapatnam 530045, AP, India

[4] CSIR, IICT, Bioengn & Environm Sci, Hyderabad 500006, TS, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 31期

关键词：

1,3-dipolar cycloaddition; 3-aryl-1-(pyridin-2-yl)-prop-2-en-1-one; multi-component reactions; Spiroxindole-Pyrrolidine; TiO2; nanoparticles; 1,3-DIPOLAR CYCLOADDITION REACTIONS; DIASTEREOSELECTIVE SYNTHESIS; AZOMETHINE YLIDES; ONE-POT; STEREOSELECTIVE-SYNTHESIS; HETEROGENEOUS CATALYSIS; FACILE SYNTHESIS; EFFICIENT; REGIO; WATER;

D O I：

10.1002/slct.201801639

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report TiO2 nanoparticle as a reusable heterogeneous catalyst for rapid synthesis of Spiroxindole-Pyrrolidine by reacting of 3-aryl-1-(pyridin-2-yl)-prop-2-en-1-one, isatins and benzylamines via 1,3-dipolar cycloaddition reaction using water as reaction media. The reaction proceeded with excellent regio and diastereoselective product formation along with good yields within 30 minutes. Structure of the product was unambiguously confirmed by single crystal X-ray diffraction study. Synthesized Spiroxindole-Pyrrolidine derivatives were evaluated for antimicrobial activity and found that all the compounds performed well against standard streptomycin drug.

引用

页码：9096 / 9101

页数：6

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