Straightforward synthesis of enantiopure 2-aminomethyl and 2-hydroxymethyl pyrrolidines with complete stereocontrol

被引：51
|
作者：
Marradi, M
Cicchi, S
Delso, JI
Rosi, L
Tejero, T
Merino, P
Goti, A [1 ]
机构：
[1] Univ Florence, CNR, ICCOM, Dipartimento Chim Organ, I-50019 Florence, Italy
[2] Univ Zaragoza, CSIC,Dept Quim Organ, Fac Ciencias,Lab Sintesis Asimetr, Inst Ciencia Mat Aragon, E-50009 Zaragoza, Spain
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 08期
关键词：
D O I：
10.1016/j.tetlet.2004.12.119
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical synthesis of 2-aminomethyl- and 2-hydroxymethyl-3,4-dihydroxypyrrolidines via stereocontrolled addition of TMSCN and LiCH2OMOM to chiral 3,4 dihydro-2H-pyrroline N-oxides is reported. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1287 / 1290
页数：4
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