Depsides and depsidones from the soil-derived fungus Aspergillus unguis PSU-RSPG204

被引：18

作者：

Phainuphong, Patima ^{[1
,2
]}

Rukachaisirikul, Vatcharin ^{[1
,2
]}

Phongpaichit, Souwalak ^{[3
]}

Sakayaroj, Jariya ^{[4
]}

Kanjanasirirat, Phongthon ^{[5
]}

Borwornpinyo, Suparerk ^{[5
]}

Akrimajirachoote, Nattaphong ^{[6
]}

Yimnual, Chantapol ^{[6
]}

Muanprasat, Chatchai ^{[5
,6
]}

机构：

[1] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand

[2] Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Songkhla, Thailand

[3] Prince Songkla Univ, Fac Sci, Dept Microbiol, Hat Yai 90112, Songkhla, Thailand

[4] Walailak Univ, Sch Sci, Tha Sala 80161, Nakhon Si Thamm, Thailand

[5] Mahidol Univ, Fac Sci, Excellent Ctr Drug Discovery, Bangkok 10400, Thailand

[6] Mahidol Univ, Fac Sci, Dept Physiol, Bangkok 10400, Thailand

来源：

TETRAHEDRON | 2018年 / 74卷 / 39期

关键词：

Aspergillus unguis; Depsides; Depsidones; Antibacterial; Antifungal; CFTR inhibition; Cytotoxic; METABOLITES; DERIVATIVES; PHTHALIDE;

D O I：

10.1016/j.tet.2018.07.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new depsides, aspergisides A-C, and one new depsidone, aspergisidone, were isolated from the soil-derived fungus Aspergillus unguis P5U-RSPG204 together with one phthalide derivative and 11 depsidones including emeguisin A, aspersidone and folipastatin. The structures were determined by spectroscopic evidence. Aspersidone and emeguisin A showed remarkably antibacterial activity against Staphylococcus aureus and methicillin-resistance S. aureus with equal MIC values of 0.5 mu g/mL. Emeguisin A, which displayed the highest activity with 87.06% inhibition of human colon carcinoma (HCT-116) cell viability, decreased numbers of live cells/numbers of dead cells in a dose-dependent manner with the IC50 values of 34.8-84.7 mu M in a 3D culture model depending on durations of incubation. In addition, folipastatin dose-dependently inhibited forskolin-stimulated chloride secretion in human intestinal epithelial (T84) cells with an IC50 value of 0.5 mu M. These depsidones were considered to be inactive against noncancerous Vero Cells with the IC50 values of >10 mu M. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：5691 / 5699

页数：9

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