Enhanced Diagnosis of Pandemic (H1N1) 2009 Influenza Infection Using Molecular and Serological Testing in Intensive Care Unit Patients with Suspected Influenza

被引：22

作者：

Iwasenko, Jenna M. ^{[1
]}

Cretikos, Michelle ^{[2
,3
]}

Paterson, David L. ^{[7
,8
]}

Gibb, Robert ^{[7
,8
]}

Webb, Steven A. ^{[9
]}

Smith, David W. ^{[10
,11
,12
]}

Blyth, Christopher C. ^{[4
]}

Dwyer, Dominic E. ^{[4
]}

Shi, Jane Q. ^{[1
]}

Robertson, Peter ^{[1
]}

Rawlinson, William D. ^{[1
,5
,6
]}

机构：

[1] Prince Wales Hosp, S Eastern Area Lab Serv, Dept Microbiol, Randwick, NSW 2031, Australia

[2] New S Wales Dept Hlth, Sydney, NSW, Australia

[3] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

[4] Westmead Hosp, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol, Westmead, NSW 2145, Australia

[5] Univ New S Wales, Fac Sci, Sch Biotechnol & Biomol Sci, Kensington, NSW 2033, Australia

[6] Univ New S Wales, Fac Med, Sch Med Sci, Kensington, NSW 2033, Australia

[7] Univ Queensland, Clin Res Ctr, Brisbane, Qld, Australia

[8] Cent Microbiol Lab, Brisbane, Qld, Australia

[9] Royal Perth Hosp, Intens Care Unit, Perth, WA, Australia

[10] Queen Elizabeth II Med Ctr, PathW Lab Med WA, Nedlands, WA, Australia

[11] Univ Western Australia, Fac Life & Phys Sci, Sch Biomed & Chem Sci, Nedlands, WA 6009, Australia

[12] Univ Western Australia, Fac Med Dent & Hlth Sci, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 51卷 / 01期

关键词：

VIRUS; IDENTIFICATION;

D O I：

10.1086/653610

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the 2009 outbreak of pandemic (H1N1) 2009 influenza (pH1N1) in Australia, acute and convalescent serum specimens were collected from 33 patients with severe respiratory disease admitted to intensive care units. Using hemagglutination inhibition of pH1N1, 29 paired serum samples showed significant increases in specific antibody titers. Of these 29 patients, 18 had pH1N1 RNA detected by routine nucleic acid testing. These results indicate that up to one-third of pH1N1 cases may not have laboratory confirmation of infection unless serological testing is included for suspected cases.

引用

页码：70 / 72

页数：3

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