Glyoxylic acid and MP-glyoxylate: Efficient formaldehyde equivalents in the 3-CC of 2-aminoazines, aldehydes, and isonitriles

被引：62

作者：

Lyon, MA ^{[1
]}

Kercher, TS ^{[1
]}

机构：

[1] Array BioPharma Inc, Boulder, CO 80301 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 26期

关键词：

D O I：

10.1021/ol0478234

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Glyoxylic acid, either in solution or immobilized on MP-carbonate (MP-glyoxylate), participates in an uncatalyzed 3-CC with 2-aminoazines and isonitriles to afford novel 2-unsubstituted-3-amino-imidazoheterocycles. MP-glyoxylate serves as a particularly efficient and experimentally convenient formaldehyde equivalent and readily liberates products through decarboxylation/self-release from the resin. These examples furthermore constitute the first application in which MP-CO3 serves as a solid support for transformations involving carboxylic acids.

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收藏

页码：4989 / 4992

页数：4

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