Recognition of Risk for Clinically Significant Drug Interactions among HIV-Infected Patients Receiving Antiretroviral Therapy

被引：66

作者：

Evans-Jones, John G. ^{[2
]}

Cottle, Lucy E. ^{[3
]}

Back, David J. ^{[1
]}

Gibbons, Sara ^{[1
]}

Beeching, Nicholas J. ^{[3
]}

Carey, Peter B. ^{[2
]}

Khoo, Saye H. ^{[1
,2
]}

机构：

[1] Univ Liverpool, Sch Biomed Sci, Dept Pharmacol, Liverpool L69 3GE, Merseyside, England

[2] Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Dept Genitourinary Med, Liverpool, Merseyside, England

[3] Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Dept Infect Dis, Liverpool, Merseyside, England

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 50卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1086/652149

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the risk of clinically significant drug interactions in patients receiving antiretrovirals, and their recognition by physicians. Clinically significant drug interactions were recorded in 27% of 159 patients, with 15% of interactions potentially lowering antiretroviral concentrations. Risk of clinically significant drug interactions was significantly related to receipt of protease inhibitors. Only 36% of clinically significant drug interactions were correctly identified by physicians.

引用

页码：1419 / 1421

页数：3

共 9 条

[1] Assessment of healthcare professionals' knowledge about warfarin-vitamin K drug-nutrient interactions [J].

Couris, RR ;

Tataronis, GR ;

Dallal, GE ;

Blumberg, JB ;

Dwyer, JT .

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2000, 19 (04) :439-445

[2] Discrepancies between medical and pharmacy records for patients on anti-HIV drugs [J].

de Maat, MMR ;

Frankfort, SV ;

Mathôt, RAA ;

Mulder, JW ;

Meenhorst, PL ;

van Gorp, ECM ;

Koks, CHW ;

Hoetelmans, RMW ;

de Boer, A ;

Beijnen, JH .

ANNALS OF PHARMACOTHERAPY, 2002, 36 (03) :410-415

[3]

*EL MED COMP, SUMM PROD CHAR

[4] Evaluation of outpatient computerized physician medication order entry systems: A systematic review [J].

Eslami, Saeid ;

Abu-Hanna, Ameen ;

De Keizer, Nicolette F. .

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2007, 14 (04) :400-406

[5]

KIGEN G, 2008, 9 INT C DRUG THER HI

[6] Evaluation of clinical pharmacist interventions on drug interactions in outpatient pharmaceutical HIV-care [J].

Maat, MMR ;

Boer, A ;

Koks, CHW ;

Mulder, JW ;

Meenhorst, PL ;

Gorp, ECM ;

Mairuhu, ATA ;

Huitema, ADR ;

Beijnen, JH .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2004, 29 (02) :121-130

[7] Prevalence and risk factors for clinically significant drug interactions with Antiretroviral therapy [J].

Miller, Christopher D. ;

El-Kholi, Ramy ;

Faragon, John J. ;

Lodise, Thomas P. .

PHARMACOTHERAPY, 2007, 27 (10) :1379-1386

[8] Antiretroviral medication errors among hospitalized patients with HIV infection [J].

Rastegar, Darius A. ;

Knight, Amy M. ;

Monolakis, Jim S. .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (07) :933-938

[9]

SHAH S, 2007, 14 C RETR OPP INF AL

← 1 →