Liquid-Liquid Phase Separation in Nucleation Process of Biomineralization

被引:23
作者
Qin, Da [1 ]
He, Zhen [1 ]
Li, Peng [1 ]
Zhang, Shutian [1 ]
机构
[1] Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Dept Gastroenterol, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
liquid-liquid phase separation; biomineralization; nucleation; prenucleation clusters; polymer-induced liquid precursor; CALCIUM-OXALATE CRYSTALLIZATION; IN-SITU; BIOMIMETIC MINERALIZATION; POTENTIAL INTERMEDIATE; CARBONATE; COLLAGEN; EGGSHELL; PRECURSORS; HYDROGELS; NANOSTRUCTURES;
D O I
10.3389/fchem.2022.834503
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Biomineralization is a typical interdisciplinary subject attracting biologists, chemists, and geologists to figure out its potential mechanism. A mounting number of studies have revealed that the classical nucleation theory is not suitable for all nucleation process of biominerals, and phase-separated structures such as polymer-induced liquid precursors (PILPs) play essential roles in the non-classical nucleation processes. These structures are able to play diverse roles biologically or pathologically, and could also give inspiring clues to bionic applications. However, a lot of confusion and dispute occurred due to the intricacy and interdisciplinary nature of liquid precursors. Researchers in different fields may have different opinions because the terminology and current state of understanding is not common knowledge. As a result, our team reviewed the most recent articles focusing on the nucleation processes of various biominerals to clarify the state-of-the-art understanding of some essential concepts and guide the newcomers to enter this intricate but charming field.
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页数:11
相关论文
共 106 条
[1]   Phase separation drives aberrant chromatin looping and cancer development [J].
Ahn, Jeong Hyun ;
Davis, Eric S. ;
Daugird, Timothy A. ;
Zhao, Shuai ;
Quiroga, Ivana Yoseli ;
Uryu, Hidetaka ;
Li, Jie ;
Storey, Aaron J. ;
Tsai, Yi-Hsuan ;
Keeley, Daniel P. ;
Mackintosh, Samuel G. ;
Edmondson, Ricky D. ;
Byrum, Stephanie D. ;
Cai, Ling ;
Tackett, Alan J. ;
Zheng, Deyou ;
Legant, Wesley R. ;
Phanstiel, Douglas H. ;
Wang, Gang Greg .
NATURE, 2021, 595 (7868) :591-+
[2]   Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates [J].
Alberti, Simon ;
Gladfelter, Amy ;
Mittag, Tanja .
CELL, 2019, 176 (03) :419-434
[3]   Mechanism of formation of concentrically laminated spherules: implication to Randall's plaque and stone formation [J].
Amos, Fairland F. ;
Dai, Lijun ;
Kumar, Rajendra ;
Khan, Saeed R. ;
Gower, Laurie B. .
UROLOGICAL RESEARCH, 2009, 37 (01) :11-17
[4]  
Antebi B, 2013, TISSUE ENG PART C-ME, V19, P487, DOI [10.1089/ten.TEC.2012.0452, 10.1089/ten.tec.2012.0452]
[5]   Stable Prenucleation Calcium Carbonate Clusters Define Liquid-Liquid Phase Separation [J].
Avaro, Jonathan T. ;
Wolf, Stefan L. P. ;
Hauser, Karin ;
Gebauer, Denis .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (15) :6155-6159
[6]   Integrating the PILP-mineralization process into a restorative dental treatment [J].
Bacino, Margot ;
Girn, Vishavjeet ;
Nurrohman, Hamid ;
Saeki, Kuniko ;
Marshall, Sally J. ;
Gower, Laurie ;
Saeed, Ella ;
Stewart, Ray ;
Le, Thuan ;
Marshall, Grayson W. ;
Habelitz, Stefan .
DENTAL MATERIALS, 2019, 35 (01) :53-63
[7]   Control of nacre biomineralization by Pif80 in pearl oyster [J].
Bahn, So Yeong ;
Jo, Byung Hoon ;
Choi, Yoo Seong ;
Cha, Hyung Joon .
SCIENCE ADVANCES, 2017, 3 (08)
[8]   Bone development [J].
Berendsen, Agnes D. ;
Olsen, Bjorn R. .
BONE, 2015, 80 :14-18
[9]   Formation and growth of amorphous colloidal CaCO3 precursor particles as detected by time-resolved SAXS [J].
Bolze, J ;
Peng, B ;
Dingenouts, N ;
Panine, P ;
Narayanan, T ;
Ballauff, M .
LANGMUIR, 2002, 18 (22) :8364-8369
[10]   Stoichiometry controls activity of phase-separated clusters of actin signaling proteins [J].
Case, Lindsay B. ;
Zhang, Xu ;
Ditlev, Jonathon A. ;
Rosen, Michael K. .
SCIENCE, 2019, 363 (6431) :1093-+