Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

被引：475

作者：

Sadtler, Kaitlyn ^{[1
,2
,8
]}

Estrellas, Kenneth ^{[1
,2
,8
]}

Allen, Brian W. ^{[1
,2
,8
]}

Wolf, Matthew T. ^{[1
,2
,8
]}

Fan, Hongni ^{[3
,8
]}

Tam, Ada J. ^{[3
,8
]}

Patel, Chirag H. ^{[3
,8
]}

Luber, Brandon S. ^{[4
,8
]}

Wang, Hao ^{[4
,8
]}

Wagner, Kathryn R. ^{[5
,6
,7
]}

Powell, Jonathan D. ^{[3
,8
]}

Housseau, Franck ^{[3
,8
]}

Pardoll, Drew M. ^{[3
,8
]}

Elisseeff, Jennifer H. ^{[1
,2
,8
]}

机构：

[1] Johns Hopkins Univ, Translat Tissue Engn Ctr, Wilmer Eye Inst, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Dept Oncol, Sidney Kimmel Comprehens Canc Ctr, Sch Med, Baltimore, MD 21231 USA

[4] Johns Hopkins Univ, Div Biostat & Bioinformat, Sidney Kimmel Comprehens Canc Ctr, Sch Med, Baltimore, MD 21231 USA

[5] Kennedy Krieger Inst, Hugo W Moser Res Inst, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[8] Johns Hopkins Univ, Sch Med, Bloomberg Kimmel Inst Canc Immunotherapy, Baltimore, MD USA

来源：

SCIENCE | 2016年 / 352卷 / 6283期

基金：

美国国家卫生研究院;

关键词：

SKELETAL-MUSCLE; IMMUNE-RESPONSE; EXPRESSION; INNATE; IGF-1; ACTIVATION;

D O I：

10.1126/science.aad9272

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.

引用

页码：366 / 370

页数：5

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