Continuous low surface tension and high viscosity two phases liquid separation

被引：5

作者：

Wang, Xi-Lun ^{[1
]}

Ni, Can-Hong ^{[1
]}

Chang, Jun-Wei ^{[1
]}

Chiang, Ya-Yu ^{[1
,2
]}

机构：

[1] Natl Chung Hsing Univ, Dept Mech Engn, Taichung, Taiwan

[2] Natl Chung Hsing Univ, i Ctr Adv Sci & Technol, Taichung, Taiwan

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2022年 / 365卷

关键词：

Droplet separation; Phase separation; Continuous processing; Core-annular flow; Low surface tension; High viscosity sample; SLUG FLOW; EXTRACTION;

D O I：

10.1016/j.snb.2022.131957

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Continuous phase separation is an essential process for developing sustainable chemical manufacturing. A novel biphasic interface manipulation method for controllably separating an aqueous solution with an organic solvent within a core-annular liquid-liquid phase separator (CAPS) with high efficiency, low energy, and low cost is presented. The interface manipulation technique involves a stretchable helix wire placed at the core position that continuously propels the carrier phase and merges the discrete phase by altering the interfacial pressure. The purity and recovery rates for three organic solvent-water biphasic systems were studied. Complete separation at a preproduction-scale (10 mL min(-1)) flow rate and for a high viscosity sample (> 5 mPa s) was demonstrated. Furthermore, the high operability in flow rate control, compatibility with different input conditions, scalability, and automatic regulation for future continuous manufacturing of the CAPS were demonstrated.

引用

页数：11

共 42 条

[1] On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system [J].

Adamo, Andrea ;

Beingessner, Rachel L. ;

Behnam, Mohsen ;

Chen, Jie ;

Jamison, Timothy F. ;

Jensen, Klavs F. ;

Monbaliu, Jean-Christophe M. ;

Myerson, Allan S. ;

Revalor, Eve M. ;

Snead, David R. ;

Stelzer, Torsten ;

Weeranoppanant, Nopphon ;

Wong, Shin Yee ;

Zhang, Ping .

SCIENCE, 2016, 352 (6281) :61-67

[2] Membrane-Based, Liquid-Liquid Separator with Integrated Pressure Control [J].

Adamo, Andrea ;

Heider, Patrick L. ;

Weeranoppanant, Nopphon ;

Jensen, Klavs F. .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2013, 52 (31) :10802-10808

[3] THE SOLUBILITY OF ETHYL ACETATE IN WATER [J].

ALTSHULLER, AP ;

EVERSON, HE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (07) :1727-1727

[4]

Amarzguioui M., 2014, P SPE ASIA PACIFIC O

[5] Automated separation of immiscible liquids using an optically monitored porous capillary [J].

Bannock, James H. ;

Lui, Tsz Yin ;

Turner, Simon T. ;

deMello, John C. .

REACTION CHEMISTRY & ENGINEERING, 2018, 3 (04) :467-477

[6] Microscale separation of immiscible liquids using a porous capillary [J].

Bannock, James H. ;

Phillips, Thomas W. ;

Nightingale, Adrian M. ;

deMello, John C. .

ANALYTICAL METHODS, 2013, 5 (19) :4991-4998

[7] Effects of an electric field on the surface tension of conducting drops [J].

Bateni, A. ;

Amirfazli, A. ;

Neumann, A. W. .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2006, 289 (1-3) :25-38

[8]

Benz K, 2001, CHEM ENG TECHNOL, V24, P11, DOI 10.1002/1521-4125(200101)24:1<11::AID-CEAT11>3.3.CO

[9]

2-H

[10] On the pinning of interfaces on micropillar edges [J].

Berthier, J. ;

Loe-Mie, F. ;

Tran, V. -M. ;

Schoumacker, S. ;

Mittler, F. ;

Marchand, G. ;

Sarrut, N. .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2009, 338 (01) :296-303

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