Synaptotagmin-SNARE coupling enlightened

被引：5
|
作者：
Rizo, Josep [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Biochem & Pharmacol, Dallas, TX 75390 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 03期
关键词：
BINDING; COMPLEX; REVEALS; FUSION; DOMAIN;
D O I：
10.1038/nsmb0310-260
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synaptotagmins and SNAREs are known to couple Ca(2+) sensing to membrane fusion during Ca(2+)-triggered exocytosis, but unraveling the mechanism of this coupling has proven extremely difficult. Two studies in this issue now provide crucial insights into the nature of synaptotagmin-SNARE interactions and reveal unsuspected similarities between synaptotagmins and viral fusion proteins.
引用
收藏
页码：260 / 262
页数：3
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