Effects of Methanol Fraction from Leaves of Schinus terebinthifolius Raddi on Nociception and Spinal-Cord Oxidative Biomarkers in Rats with Neuropathic Pain

被引：12

作者：

Scheid, Taina ^{[1
]}

Moraes, Maira Silmara ^{[1
]}

Henriques, Thiago Pereira ^{[1
]}

Konzen Riffel, Ana Paula ^{[1
]}

Bello-Klein, Adriane ^{[1
]}

Von Poser, Gilsane Lino ^{[2
]}

Ethur, Eduardo Miranda ^{[3
]}

Partata, Wania Aparecida ^{[1
]}

机构：

[1] Univ Rio Grande Sul UFRGS, Inst Basic Hlth Sci, Dept Physiol, Porto Alegre, RS, Brazil

[2] Univ Rio Grande Sul UFRGS, Inst Pharm, Porto Alegre, RS, Brazil

[3] UNIVATES, Dept Exact & Technol Sci, Lajeado, RS, Brazil

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2018年 / 2018卷

关键词：

CHRONIC CONSTRICTION INJURY; ASCORBIC-ACID; SCIATIC-NERVE; GLUTATHIONE; RADDI; EXTRACT; NEURONS; STRESS; MODEL; ASSAY;

D O I：

10.1155/2018/5783412

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

We determined the antioxidant potential of fractions obtained from leaves of Schinus terebinthifolius, a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance. These qualities were found in the methanol fraction (MeF), which was administered intraperitoneally (20 mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. The MeF increased the mechanical and thermal thresholds that had been lowered by CCI. In parallel, the lumbosacral spinal cord showed an increase in superoxide dismutase but a decrease in glutathione peroxidase and glutathione-S-transferase activities in saline- and MeF-treated CCI rats. Catalase activity decreased only in saline-treated CCI rats for 10 days. Total thiols decreased in saline- and MeF-treated CCI rats. Ascorbic acid increased in these rats at day 3 but only in saline-treated CCI rats at day 10. No change was found in hydrogen peroxide and lipid hydroperoxide. Open-field and elevated plus-maze tests and blood parameters of liver function did not change. Thus, the MeF from leaves of S. terebinthifolius has an antinociceptive action with no toxic effects, and it affects oxidant biomarkers in the spinal cord of rats with CCI.

引用

页数：11

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