Pathological transition as the arising mechanism for drug resistance in lung cancer

被引：31

作者：

Chen, Yueqing ^{[1
,2
]}

Tang, Waiying Yvonne ^{[3
]}

Tong, Xinyuan ^{[1
,2
]}

Ji, Hongbin ^{[1
,4
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,State Key Lab Cell Biol, Innovat Ctr Cell Signaling Network,CAS Ctr Excell, Shanghai 200031, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Sunway Med Ctr, Bandar Sunway 47500, Selangor, Malaysia

[4] Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China

来源：

CANCER COMMUNICATIONS | 2019年 / 39卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Lung cancer; Drug resistance; Pathological transition; SQUAMOUS-CELL CARCINOMA; GROWING TERATOMA SYNDROME; PRIMARY ADENOSQUAMOUS CARCINOMA; ALK-REARRANGED ADENOCARCINOMA; TYROSINE KINASE INHIBITORS; FACTOR RECEPTOR MUTATION; NONSMALL CELL; HISTOLOGIC TRANSFORMATION; ACQUIRED-RESISTANCE; NEUROENDOCRINE CARCINOMA;

D O I：

10.1186/s40880-019-0402-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the tremendous efforts for improving therapeutics of lung cancer patients, its prognosis remains disappointing. This can be largely attributed to the lack of comprehensive understanding of drug resistance leading to insufficient development of effective therapeutics in clinic. Based on the current progresses of lung cancer research, we classify drug resistance mechanisms into three different levels: molecular, cellular and pathological level. All these three levels have significantly contributed to the acquisition and evolution of drug resistance in clinic. Our understanding on drug resistance mechanisms has begun to change the way of clinical practice and improve patient prognosis. In this review, we focus on discussing the pathological changes linking to drug resistance as this has been largely overlooked in the past decades.

引用

页数：13

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