Hypertrophic obstructive cardiomyopathy

被引：229

作者：

Veselka, Josef ^{[1
,2
]}

Anavekar, Nandan S. ^{[3
,4
]}

Charron, Philippe ^{[5
,6
]}

机构：

[1] Charles Univ Prague, Dept Cardiol, Sch Med 2, Prague 15000 5, Czech Republic

[2] Motol Univ Hosp, Prague 15000 5, Czech Republic

[3] Mayo Clin, Dept Cardiol, Rochester, MN USA

[4] Mayo Clin, Dept Radiol, Rochester, MN USA

[5] Univ Paris Sud, UVSQ, INSERM, U1018,CESP, Boulogne, France

[6] Hop La Pitie Salpetriere, APHP, ICAN, Paris, France

来源：

LANCET | 2017年 / 389卷 / 10075期

关键词：

CARDIOVASCULAR MAGNETIC-RESONANCE; ALCOHOL SEPTAL ABLATION; LEFT-VENTRICULAR HYPERTROPHY; SUDDEN CARDIAC DEATH; OUTFLOW TRACT OBSTRUCTION; LATE GADOLINIUM ENHANCEMENT; CARDIOLOGY WORKING GROUP; LONG-TERM OUTCOMES; BINDING PROTEIN-C; CONTEMPORARY MANAGEMENT STRATEGIES;

D O I：

10.1016/S0140-6736(16)31321-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypertrophic obstructive cardiomyopathy is an inherited myocardial disease defined by cardiac hypertrophy (wall thickness >= 15 mm) that is not explained by abnormal loading conditions, and left ventricular obstruction greater than or equal to 30 mm Hg. Typical symptoms include dyspnoea, chest pain, palpitations, and syncope. The diagnosis is usually suspected on clinical examination and confirmed by imaging. Some patients are at increased risk of sudden cardiac death, heart failure, and atrial fibrillation. Patients with an increased risk of sudden cardiac death undergo cardioverter-defibrillator implantation; in patients with severe symptoms related to ventricular obstruction, septal reduction therapy (myectomy or alcohol septal ablation) is recommended. Life-long anticoagulation is indicated after the first episode of atrial fibrillation.

引用

页码：1253 / 1267

页数：15

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