Malignant Uveal Schwannoma With Peripheral Nerve Extension in a 12-Week-Old Color-Dilute Labrador Retriever

被引:6
作者
Duke, F. D. [1 ]
Teixeira, L. B. C. [1 ]
Galle, L. E. [2 ]
Green, N. [3 ]
Dubielzig, R. R. [1 ]
机构
[1] Univ Wisconsin, Sch Vet Med, Madison, WI 53706 USA
[2] Mississippi Vet Ophthalmol Specialists, Ocean Springs, MS USA
[3] Anim Care Ctr, Mobile, AL USA
关键词
canine; eye; color dilute; juvenile; neurofibromatosis; schwannoma; uveal schwannoma of blue-eyed dogs; BLUE-EYED DOGS; MELANOTIC SCHWANNOMA; SHEATH TUMOR; NEUROFIBROMATOSIS;
D O I
10.1177/0300985814522811
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The formalin-fixed, amber-colored right globe from a 12-week-old female silver Labrador Retriever dog was submitted to the Comparative Ocular Pathology Laboratory of Wisconsin for light microscopic evaluation. The clinical history described a collapsed anterior chamber and multifocal nodular lesions in the peripheral iris. Histologically, immunohistochemically, and ultrastructurally, the uveal mass was consistent with a malignant schwannoma; there was extension along peripheral nerves within the sclera. The signalment and behavior of the neoplasm distinguish it from the uveal schwannoma of blue-eyed dogs and bear some resemblance to the ocular lesions in human neurofibromatosis. The dilute color mutation may contribute to the cause. Six weeks later, the dog did not develop any additional masses.
引用
收藏
页码:181 / 185
页数:5
相关论文
共 15 条
[1]   Unilateral limb enlargement in a dog with a malignant peripheral nerve sheath tumor [J].
Brower, A ;
Salamat, S ;
Crawford, J ;
Manley, P .
VETERINARY PATHOLOGY, 2005, 42 (03) :353-356
[2]   Metastatic uveal schwannoma of blue-eyed dogs [J].
Duke, Felicia D. ;
Brudenall, Denise K. ;
Scott, Erin M. ;
Teixeira, Leandro B. C. ;
Dubielzig, Richard R. .
VETERINARY OPHTHALMOLOGY, 2013, 16 :141-144
[3]  
FAN JT, 1995, CAN J OPHTHALMOL, V30, P37
[4]   CASE OF NEUROFIBROMATOSIS IN DOG [J].
GOEDEGEBUURE, SA .
JOURNAL OF SMALL ANIMAL PRACTICE, 1975, 16 (05) :329-335
[5]  
Huang HY, 2004, APPL IMMUNOHISTO M M, V12, P50
[6]   Malignant peripheral nerve sheath tumor with divergent mesenchymal differentiations in a dog [J].
Kim, DY ;
Cho, DY ;
Kim, DY ;
Lee, J ;
Taylor, HW .
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2003, 15 (02) :174-178
[7]  
Kurtkaya-Yapicier Ö, 2003, HISTOL HISTOPATHOL, V18, P925, DOI 10.14670/HH-18.925
[8]  
Lakkis MM, 2000, J NEUROSCI RES, V62, P755, DOI 10.1002/1097-4547(20001215)62:6<755::AID-JNR1>3.0.CO
[9]  
2-W
[10]   Diagnostic criteria for schwannomatosis [J].
MacCollin, M ;
Chiocca, EA ;
Evans, DG ;
Friedman, JM ;
Horvitz, R ;
Jaramillo, D ;
Lev, M ;
Mautner, VF ;
Niimura, M ;
Plotkin, SR ;
Sang, CN ;
Stemmer-Rachamimov, A ;
Roach, ES .
NEUROLOGY, 2005, 64 (11) :1838-1845